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Clemens Scherzer, MD

Inaugural Director and
Stephen & Denise Adams
Professor of Neurology

Stephen & Denise Adams Center for Parkinson's Disease Research
of Yale School of Medicine

Email: clemens.scherzer@yale.edu


How does the human genome program 86 billion highly specialized neurons in the human brain? How is this program disrupted by diseases of the brain? In the inter-disciplinary Neurogenomics Lab, genomicists, computational and clinical scientists use Big Data to search for the answers to these big questions. We use next-generation genomics technologies to identify the complete set of building blocks and instructions needed to make healthy human brain cells and to discover which are defective in Parkinson’s, Huntington’s, and Alzheimer’s disease. In our translational work we use genome, epigenome, metabolome, and digital health IT to develop a future personalized medicine for patients with Parkinson's and other neurologic diseases designed to diagnose and treat the right patient, with the right medicine, at the right time.

Dr. Gilbert Hosts: Genetics and Parkinson's Disease with Dr. Clemens Scherzer.

Clemens Scherzer on the hunt for genes that drive Parkinson's disease progression

Genomic dark matter and personalized medicine

Launch of new Adams Center for Parkinson Precision Medicine. YSM News, April 1, 2024 More

New Yale Parkinson Center. Yale Daily News, 2023 More

Yale Recruits Scherzer. YSM News, October, 2023 More

Circular RNAs Identified in Vulnerable Brain Cells. GEN News, September, 2023 More

ASAP Initiative's $9 million gift elevates Parkinson's research. Brigham Health Breakthroughs Because of You. Fall 2021 » More

Novel Genes May Drive Progression in Parkinson's Disease Neurology Today, June 17, 2021 More

The Genetic Architecture of How Parkinson's Disease Progresses Is Revealed Technology Networks, 2021 » More

The Parkinson's Puzzle: Piecing Together a More Personalized Approach Brigham Clinical & Research News, March 2021 » More

Scherzer Team Selected for $9M Aligning Science Across Parkinson's Initiative Grant
BWH Newsroom, September 16, 2020 » more

HBS joins the Accelerating Medicines Partnership - PD »more

Genomic 'Dark Matter' and Parkinson's
By Joana Carvalho, Parkinson's News Today, 2018 »more

Precision Neurology Program launch »more

Asthma drug may thwart Parkinson's disease
By Mitch Leslie, Science, 2017 »more

New Hope From Old Drugs in Fight Against Parkinson's
By Amy Norton, U.S. News & World Report, 2017 »more

Asthma Medication May Lower Risk of Parkinson's – NOVA Next | PBS, 2017

Risk Score Forecasts Cognitive Decline in Parkinson's, Alzforum, June 30, 2017

Predicting cognitive deficits in people with Parkinson's disease, National Institutes of Health, June 21, 2017

New Tool May Help Researchers Predict Cognitive Decline with Parkinson's Disease, FoxFeed Blog, June 23, 2017

Linking Gaucher and Parkinson's Diseases, DNA Science Blog, December 8, 2016 »more

Mutations in GBA Gene Linked to Parkinson's Cognitive Decline, FoxFeed Blog, December 1, 2016 »more

Parkinson's Disease and Cognitive Decline: Genetic Link Revealed, BWH Bulletin, December 2, 2016 »more

Hot Topic: A New Biomarker for Parkinson’s Disease?
Movement Disorders, December 15, 2015 »more

Alpha-synuclein: Promising molecular test for Parkinson's disease, NETPR Highlights, 2015 »more

A glimpse into the future of biomedicine
Science Translational Medicine, 2014 »more

Michael J. Fox Foundation Awards
February 2014 »more

The Harvard Biomarker Study's big plan
Lancet Neurology, June 26, 2013 »more

Biomarker for Huntington's disease identified
Harvard Gazette, October 3, 2011 »more

Study: Brain energy crisis may spark Parkinson's
The Washington Post, November 2, 2010 »more

Clemens Scherzer on cutting-edge Parkinson’s research
EarthSky, November 29, 2010 »more

Study links Parkinson’s to brain’s tiny power factories
Boston Globe, November 2, 2010 »more

Damaged cell powerhouses linked to Parkinson's
Nature, October 6, 2010 »more

Transcriptional regulation of α-synuclein: insights from blood?
Future Neurology, March 2009 »more

Interview - Searching for biomarkers in Parkinson's disease
Biomarkers in Medicine, April, 2009 »more

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